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Publications

Coelho, C. H., M. Durigan, D. A. G. Leal, A. B. Schenider, R. M. M. Franco and S. M. Singer (2017) Giardiasis as a neglected disease in Brazil: systematic review of 20 years of publications. PLoS Neglected Tropical Diseases. PubMed

Nooshadokht, M., Kalantari-Khandani, B., Sharif, I., Kamyabi, H., Kagnoff, M. F., Eckmann, L., Singer, S. M., Babaei, Z., and Solaymani-Mohammadi, S. (2017) Giardia duodenalis infection among human subjects with HIV/AIDS and cancer: significance of a stool antigen immunodetection-based modality for diagnosis. J. Microbio. Methods. 141: 35-41. PubMed

Bartelt, L.A., D. T. Bolick, J. Mayneris-Perxachs, G. L. Kolling, G. L. Medlock, E. I. Zaenker, J. Donowitz, R. V. Thomas-Beckett, A. Rogala, I. M. Carroll, S. M. Singer, J. Papin, J. R. Swann, and R. L. Guerrant (2017) Cross-modulation of pathogen-specific pathways enhances malnutrition during enteric co-infection with Giardia lamblia and enteroaggregative Escherichia coli. PLoS Pathogens. 13: e1006471 PubMed

Barash N. R., J. G. Maloney, S. M. Singer and S. C. Dawson. (2017) Giardia alters commensal microbial diversity throughout the murine gut. Inf. Immun. 85: e00948-16. PubMed

Coelho, C. H., A. O. Costa, A. C. C. Silva, M. M. Pucci, A. V. Serufo, H. G. N. O. Busatti, M. Durigan, J. Perales, A. Chapeaurouge, D. A. da Silva e Silva, M. A. Gomes, J. S. Toledo, S. M. Singer, R. A. Silva-Pereira and A. P. Fernandes. (2016) Genotyping and Descriptive Proteomics of a Potential Zoonotic Canine Strain of Giardia duodenalis, Infective to Mice. PLoS ONE 11(10): e0164946. PubMed

Keselman A., E. Li, J. Maloney and S. M. Singer. (2016) The Microbiota Contributes to CD8+ T cell Activation and Nutrient Malbsorption Following Intestinal Infection with Giardia. Inf. Immun. 84: 2853-2860. PubMed

Babaei, Z., N. Malihi, N. Zia-Ali, I. Sharifi, M. Mohammadi, M. Kagnoff, L. Eckmann, S. M. Singer and S. Solaymani-Mohammadi.  (2016) Adaptive Immune Response in Symptomatic and Asymptomatic Enteric Protozoal Infection: Roles of Parasite Genetic Heterogeneity. Microbes Infect. 11: 867-695.  PubMed

Li, E., E. Tako and S. M. Singer.  (2016) Activation of Complement through the Lectin Pathway is Important for Control of Giardia duodenalis Infection in Mice by Recruiting Mast Cells through C3a Receptor. Infect Immun. 84: 1092-99. PubMed

Tosh, K., L. Mittereder, S. Bonne-Annee, S. Hieny, T. B. Nutman, S. M. Singer, A. Sher and D. Jankovic (2016) The IL-12 response of primary human DC and monocytes to Toxoplasma gondii is stimulated by phagocytosis of live parasites rather than host cell invasion. J Imm. 196: 345-56. PubMed

Solaymani-Mohammadi, S., O. Lakhdari, I. Minev, S. Shenouda, B. F. Frey, R. Billeskov, S. M. Singer, J. A. Berzofsky, L. Eckmann and M. F. Kagnoff (2016) Lack of the programmed death-1 receptor renders host susceptible to enteric microbial infection through impairing the production of the mucosal natural killer cell effector molecules. J Leuk Biol. 99: 475-482. PubMed

Maloney, J.G., A. Keselman, E. Li, and S. M. Singer (2015) Macrophages expressing Arginase 1 and Nitric oxide synthase 2 accumulate in the small intestine during Giardia lamblia infection. Microbes Infect, 17: 462-67. PubMed

Li, E., M. Liu and S. M. Singer (2014) Resistance to Reinfection in Mice as a Vaccine Model for Giardiasis. Hum Vacc & Immuno 10: 1536-43. PubMed

Tako, E., E. Li, M. Farzad and S. M. Singer.  (2013)  Transcriptomic Analysis of Host Response to Giardia duodenalis Infection Reveals Redundant Mechanisms for Pathogen Control. mBIO, 4: e00660-13.  PubMed

Bartelt, L. A., Roche, J., Kolling, G., Bolick, D., Noronha, F., Naylor, C., Hoffman, P., Warren, C., Singer, S., and R.  Guerrant.  (2013) Persistent G. lamblia impairs growth in a novel murine-malnutrition model.  J Clin Invest. 123: 2672-84.  PubMed

Solaymani-Mohammadi, S and S. M. Singer.  (2013) Regulation of intestinal epithelial cell cytoskeletal remodeling by cellular immunity following gut infection.  Muc Immunol. 6:369-78.   PubMed

Kamda, J. D., Nash, T. E. and S. M. Singer. (2012) Giardia duodenalis: dendritic cell defects in IL-6 deficient mice contribute to susceptibility to intestinal infection.  Exp Parasitol.  130: 288-91.   PubMed

Solaymani-Mohammadi, S and S. M. Singer.  (2011) Host immunity and pathogen strain contribute to intestinal disaccharidase impairment following gut infection.  J Immunol. 187:3769-75.   PubMed

Solaymani-Mohammadi, S., J. M. Genkinger, C. A. Loffredo and S. M. Singer (2010) A meta-analysis of the effectiveness of albendazole compared with metronidazole as treatments for infections with Giardia duodenalis. PLoS Negl Trop Dis. 4: e682.   PubMed

Kamda, J. D. and S. M. Singer. (2009) Phosphoinositide 3-Kinase Dependent Inhibition of Dendritic Cell IL-12 Production by Giardia lamblia. Infect and Immun.  77: 685-93.   PubMed

Li, E., A. Zhao, T. Shea-Donohue, and S. M. Singer. (2007) Mast Cell Mediated Changes in Smooth Muscle Contractility During Mouse Giardiasis. Infect and Immun. 72: 6642-49.   PubMed

Zhou, P., E. Li, T. Shea-Donohue, and S. M. Singer. (2007) Tumor Necrosis Factor alpha Contributes to Protection Against Giardia lamblia Infection in Mice. Parasite Immunol. 29: 367–374.   PubMed

Kulakova, L., S. M. Singer, J. Conrad and T. E. Nash. (2006) Epigenetic mechanisms are involved in the control of Giardia lamblia antigenic variation.  Mol. Micro. 61:1533-42.   PubMed

Li, E., P. Zhou, and S. M. Singer. (2006)  Neuronal nitric oxide synthase but not inducible nitric oxide synthase is required for control of Giardia lamblia infections in mice. J. Immunol. 176(1):516-21.   PubMed

Hausmann, S., M. A. Altura, M. Witmer, S. M. Singer, H. G. Elmendorf, and S. Shuman.  (2005) Yeast-like mRNA capping apparatus in Giardia lamblia.  J Biol Chem. 280:12077-86.   PubMed

Li, E., P. Zhou, Z. Petrin, and S. M. Singer. (2004) Mast cell dependent control of Giardia lamblia infections in mice.  Infect and Immun 72(11): 6642-6649.   PubMed

Zhou, P., E. Li, N. Zhu, J. Robertson, T. E. Nash, and S. M. Singer. (2003) Role of Interleukin-6 in the Control of Acute and Chronic Giardia lamblia Infections in Mice. Infect and Immun. 71(3):1566-8.    PubMed

Singer, S. M., H. G. Elmendorf, J. T. Conrad and T. E. Nash. (2001) Biological Selection of Variant-specific Surface Proteins in Giardia lamblia, J of Infect Dis. 183:119-124.   PubMed

Elmendorf, HG, S. M. Singer, J. Pierce, J. Cowan and T. E. Nash. (2001) Initiator and Upstream Elements in the Alpha-2 Tubulin Promoter of Giardia lamblia, Mol. Biochem. Parasit. 113:157-169.   PubMed

Elmendorf, HG, S. M. Singer and T. E. Nash.  (2001) The Abundance of Sterile Transcripts in Giardia lamblia. Nucleic Acids Research  29:4674-83.   PubMed

Singer, S. M. and T. E. Nash. (2000) T cell dependent control of acute Giardia lamblia infections in mice, Infect and Immun 68: 170-175.   PubMed

Elmendorf, H. G., S. M. Singer and T. E. Nash. (2000)  Targeting of Proteins to the Nuclei of Giardia lamblia, Mol. Biochem. Parasit. 106: 315-319.   PubMed

Singer, S. M. and T. E. Nash. (2000) The role of normal flora in infections by Giardia lamblia, J of Infect Dis  181: 1510-1512.   PubMed

Späth, G. F., L. Epstein, B. Leader, S. M. Singer, H. Avila, S. J. Turco and S. M. Beverley. (2000)  Lipophosphoglycan (LPG) is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major, Proc. Natl. Acad. Sci. U. S. A. 97: 9258-9263.   PubMed

Singer, S. M., J. Yee, and T. E. Nash. (1998) Episomal and Integrated Maintenance of Foreign DNA in Giardia lamblia. Mol. Biochem. Parasit. 92: 59-69.   PubMed

Singer, S. M., R. Tisch, X.-D. Yang, H.-K. Sytwu, R. S. Liblau and H. O. McDevitt. (1998) Prevention of diabetes in NOD mice by a mutated I-Ab transgene. Diabetes 47: 1570-1577.   PubMed

Wherret, D., S. M. Singer, and H. O. McDevitt.  (1997)  Reduction in Diabetes Incidence in an I-Ag7 Transgenic Nonobese Diabetic Mouse Line.  Diabetes  46: 1970-1974.   PubMed

Singer, S. M., D. T. Umetsu, and H. O. McDevitt.  (1996)  High Copy Number I-Ab Transgenes Induce Production of IgE through an Interleukin 4-Dependent Mechanism,. Proc. Natl. Acad. Sci. U.S. A. 93: 2947-2952.   PubMed

Yang X.D., R. Tisch, S. M. Singer, Z.A. Cao, R. S. Liblau, R.D. Schreiber and H. O. McDevitt.  (1994)  Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process.  J Exp Med. 180: 995-1004.   PubMed

Gelber C., L. Paborsky, S. M. Singer, D. McAteer, R. Tisch, C. Jolicoeur, R. Buelow, H. McDevitt, and C. G.  Fathman. (1994)  Isolation of nonobese diabetic mouse T-cells that recognize novel autoantigens involved in the early events of diabetes.  Diabetes 43: 33-9.    PubMed

Tisch, R., X.-D. Yang, S. M. Singer, R. S. Liblau, L. Fugger, and H. O. McDevitt. (1993)  Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.  Nature 366: 72-75.   PubMed

Singer, S. M., R. Tisch, X.-D. Yang, and H. O. McDevitt.  (1993)  An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells. Proc. Natl. Acad. Sci. U.S. A. 90: 9566-9570.   PubMed

 

Reviews and Book Chapters

Fink, M. Y. and S. M. Singer (2017) The Intersection of Immune Responses, Microbiota and Pathogenesis in Giardiasis. Trends Parasit. PubMed

S. M. Singer, J. G. Maloney and C. H. Coelho (2017) Chapter 40: Giardia lamblia, in Laboratory Models For Foodborne Infection. D. Liu ed. (Taylor & Francis: New York).

Quach, J., K. Chadee, J. Mead and S. M. Singer (2016) Immunity to Intestinal Protozoa: Entamoeba, Cryptosporidium, and Giardia, in Encyclopedia of Immunology, Vol. 4, M. J. H.  Ratcliffe ed. (Elsevier: New York) pp. 133-141.

S. M. Singer, (2016) Control of Giardiasis by IL-17 in Humans and Mice - Are the Questions all Answered? Invited Commentary in Clin Vacc Imm 23:2-5. PubMed

S. M. Singer (2012) Giardiasis, in Immunology of Parasitic Infections, T. Lamb. ed., Wiley-Blackwell: Hoboken, NJ. pp. 139-152.

S. M. Singer (2011) Immunology of Giardiasis, in Giardia, S. Svard and H. Lujan. Eds., Springer-Verlag: New York. pp. 319-331.

Solaymani-Mohammadi, S. and S.M. Singer (2010) Giardia duodenalis:  The Double-edged Sword of Immune Responses in Giardiasis, Exp Parasit. 126:292-297.

Keselman, A. and S. M. Singer (2010) Immunity to Giardiasis, in Immune Response to Parasitic Infections, O. Brandonisio and  E. Jirillo eds., Bentham Science Publishers Inc.: New York. pp.78-97.  http://www.bentham.org/ebooks/9781608051489/index.htm.

S. M. Singer and J. D. Kamda (2009) Immune Response to Giardia infection:  Lessons from Animal Models, in Proceedings of the International Giardia and Cryptosporidium Conference II. ed. Ortega- Pierres, G. CAB International: Oxfordshire, UK. pp. 451-462.
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